At the international level, he represents Malawi. He plays primarily as a Defender.

His most recent move was a from Big Bullets FC to FC Platinum on 2025-02-21.

Throughout the FIFA World Cup qualification (CAF) 2026, Nickson Nyasulu featured in 5 matches, averaging 0 tackles, 0 interceptions, and 0 clearances per game, while blocking 0 shots per game.